期刊
EMBO REPORTS
卷 14, 期 7, 页码 638-644出版社
WILEY
DOI: 10.1038/embor.2013.72
关键词
ATPase inhibitory factor 1; cellular differentiation; H+-ATP synthase; mitochondria; protein degradation
资金
- Junta Ampliacion Estudios-Consejo Superior de Investigaciones Cientificas
- Formacion Personal Investigador-Ministerio Educacion y Ciencia
- Formacion Personal Investigador-Universidad Autonoma de Madrid Spain
- Ministerio de Educacion y Ciencia [BFU2010-18903]
- Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Spain
- ISCIII, Spain
- Comunidad de Madrid, Spain [S2011/BMD-2402]
- Fundacion Ramon Areces
Differentiation of human mesenchymal stem cells (hMSCs) requires the rewiring of energy metabolism. Herein, we demonstrate that the ATPase inhibitory factor 1 (IF1) is expressed in hMSCs and in prostate and colon stem cells but is not expressed in the differentiated cells. IF1 inhibits oxidative phosphorylation and regulates the activity of aerobic glycolysis in hMSCs. Silencing of IF1 in hMSCs mimics the metabolic changes observed in osteocytes and accelerates cellular differentiation. Activation of IF1 degradation acts as the switch that regulates energy metabolism during differentiation. We conclude that IF1 is a stemness marker important for maintaining the quiescence state.
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