期刊
EMBO REPORTS
卷 14, 期 11, 页码 999-1007出版社
WILEY
DOI: 10.1038/embor.2013.138
关键词
chemerin peptide; inflammation; intravital microscopy; neutrophil; resolution
资金
- Sir Henry Wellcome Postdoctoral Fellowship [088967/Z/09/Z]
- Oliver Bird Studentship
- MRC PhD Studentship
- Wellcome Trust [088967/Z/09/Z] Funding Source: Wellcome Trust
Neutrophil activation and adhesion must be tightly controlled to prevent complications associated with excessive inflammatory responses. The role of the anti-inflammatory peptide chemerin15 (C15) and the receptor ChemR23 in neutrophil physiology is unknown. Here, we report that ChemR23 is expressed in neutrophil granules and rapidly upregulated upon neutrophil activation. C15 inhibits integrin activation and clustering, reducing neutrophil adhesion and chemotaxis in vitro. In the inflamed microvasculature, C15 rapidly modulates neutrophil physiology inducing adherent cell detachment from the inflamed endothelium, while reducing neutrophil recruitment and heart damage in a murine myocardial infarction model. These effects are mediated through ChemR23. We identify the C15/ChemR23 pathway as a new regulator and thus therapeutic target in neutrophil-driven pathologies.
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