期刊
EMBO REPORTS
卷 14, 期 4, 页码 337-346出版社
WILEY
DOI: 10.1038/embor.2013.29
关键词
ascorbate; dioxygenase; histone demethylase; DNA methylation; reprogramming
资金
- Wellcome Trust [087530/Z/08/A]
- Wellcome Trust [087530/Z/08/A] Funding Source: Wellcome Trust
Vitamin C is an antioxidant that maintains the activity of iron and alpha-ketoglutarate-dependent dioxygenases. Despite these enzymes being implicated in a wide range of biological pathways, vitamin C is rarely included in common cell culture media. Recent studies show that reprogramming of pluripotent stem cells is enhanced when vitamin C is present, thereby illustrating previous limitations in reprogramming cultures. Here, we summarize understanding of dioxygenase function in reprogramming and epigenetic regulation. The available data suggest a link between dioxygenase function and stem cell differentiation, which is exposed to environmental influence and is relevant for human disease.
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