期刊
EMBO REPORTS
卷 14, 期 3, 页码 252-260出版社
WILEY
DOI: 10.1038/embor.2012.218
关键词
telomere; meiosis; spindle; spindle pole body; fission yeast
资金
- European Research Council
- Cancer Research UK
- Cancer Research UK [12097] Funding Source: researchfish
Contact between telomeres and the fission yeast spindle pole body during meiotic prophase is crucial for subsequent spindle assembly, but the feature of telomeres that confers their ability to promote spindle formation remains mysterious. Here we show that while strains harbouring circular chromosomes devoid of telomere repeat tracts undergo aberrant meiosis with defective spindles, the insertion of a single internal telomere repeat stretch rescues the spindle defects. Moreover, the telomeric overhang-binding protein Pot1 is dispensable for rescue of spindle formation. Hence, an inherent feature of the double-strand telomeric region endows telomeres with the capacity to promote spindle formation.
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