期刊
EMBO REPORTS
卷 14, 期 5, 页码 422-433出版社
WILEY
DOI: 10.1038/embor.2013.45
关键词
signal transduction; nuclear transport; cell-cell adhesion
资金
- Cancer Research Society
- Canadian Cancer Society Research Institute
After two decades of stardom, one would think that beta-catenin has revealed all of its most intimate details. Yet the essence of its duality has remained mysterious-how can a single protein both be the core link between cadherins and the cytoskeleton, and the nuclear messenger for Wnt signalling? On the basis of the available evidence and on molecular and evolutionary considerations, I propose that beta-catenin was a born nuclear transport receptor, which by interacting with adhesion molecules acquired the property to coordinate nuclear functions with cell-cell adhesion. While Wnt signalling diverted this activity, the original pathway might still function in modern eukaryotes.
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