期刊
EMBO REPORTS
卷 13, 期 6, 页码 515-527出版社
WILEY
DOI: 10.1038/embor.2012.65
关键词
aneuploidy; cancer; tumorigenesis; Down syndrome; genomic instability
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R29 GM056800, R01 GM056800] Funding Source: Medline
Aneuploidy is frequently associated with disease and developmental abnormalities. It is also a key characteristic of cancer. Several model systems have been developed to study the role of chromosomal instability and aneuploidy in tumorigenesis. The results are surprisingly complex, with the conditions sometimes promoting and sometimes inhibiting tumour formation. Here, we review the effects of aneuploidy and chromosomal instability in cells and model systems of cancer, propose a model that could explain these complex findings and discuss how the aneuploid condition could be exploited in cancer therapy.
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