期刊
EMBO REPORTS
卷 13, 期 10, 页码 916-922出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2012.116
关键词
redox regulation; mitochondrial import; thioredoxin; oxidoreductase; folding
资金
- Royal Society
- Biotechnology and Biological Sciences Research Council
- Leverhulme Trust
Thiol-disulphide redox regulation has a key role during the biogenesis of mitochondrial intermembrane space (IMS) proteins. Only the Cys-reduced form of precursor proteins can be imported into mitochondria, which is followed by disulphide bond formation in the mitochondrial IMS. In contrast to the wealth of knowledge on the oxidation process inside mitochondria, little is known about how precursors are maintained in an import-competent form in the cytosol. Here we provide the first evidence that the cytosolic thioredoxin system is required to maintain the IMS small Tim proteins in reduced forms and facilitate their mitochondrial import during respiratory growth.
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