期刊
EMBO REPORTS
卷 13, 期 9, 页码 847-854出版社
WILEY
DOI: 10.1038/embor.2012.93
关键词
Mps1; Aurora B; biorientation; centromere
资金
- Netherlands Organization for Scientific Research [Vidi 91766332, Vidi 91776336]
- Dutch Cancer Society [UU 2009-4311]
- European Research Council (ERC-Stg KINSIGN)
- European Communities 7th Framework Programme [241548, 258068]
- Boehringer Ingelheim Fonds
Aurora B localization to mitotic centromeres, which is required for proper chromosome alignment during mitosis, relies on Haspin-dependent histone H3 phosphorylation and on Bub1-dependent histone H2A phosphorylation-which interacts with Borealin through a Shugoshin (Sgo) intermediate. We demonstrate that Mps1 stimulates the latter recruitment axis. Mps1 activity enhances H2A-T120ph and is critical for Sgo1 recruitment to centromeres, thereby promoting Aurora B centromere recruitment in early mitosis. Importantly, chromosome biorientation defects caused by Mps1 inhibition are improved by restoring Aurora B centromere recruitment. As Mps1 kinetochore localization reciprocally depends on Aurora B, we propose that this Aurora B-Mps1 recruitment circuitry cooperates with the Aurora B-Haspin feedback loop to ensure rapid centromere accumulation of Aurora B at the onset of mitosis.
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