期刊
EMBO REPORTS
卷 13, 期 8, 页码 699-708出版社
WILEY
DOI: 10.1038/embor.2012.102
关键词
calcium; plasticity; spine; super-resolution imaging; two-photon imaging
资金
- German Research Foundation [IRTG 1373]
- ERAnet
- Friedrich Schiedel Foundation
Dendritic spines arise as small protrusions from the dendritic shaft of various types of neuron and receive inputs from excitatory axons. Ever since dendritic spines were first described in the nineteenth century, questions about their function have spawned many hypotheses. In this review, we introduce understanding of the structural and biochemical properties of dendritic spines with emphasis on components studied with imaging methods. We then explore advances in in vivo imaging methods that are allowing spine activity to be studied in living tissue, from super-resolution techniques to calcium imaging. Finally, we review studies on spine structure and function in vivo. These new results shed light on the development, integration properties and plasticity of spines.
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