期刊
EMBO REPORTS
卷 13, 期 6, 页码 539-546出版社
WILEY
DOI: 10.1038/embor.2012.54
关键词
cohesin; aneuploidy; chromosome segregation; meiosis; oocytes
资金
- Deutsche Forschungsgemeinschaft [SPP1384]
The trend of women to become pregnant when older than in previous generations poses a paramount medical problem, for oocytes are particularly prone to chromosome missegregation, and aneuploidy increases with age. Recent data strongly suggest that as oocyte age increases sister chromatid cohesion is weakened or lost. Cohesin deterioration seems to contribute significantly to age-dependent aneuploidy, as discussed in this review.
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