期刊
EMBO REPORTS
卷 13, 期 8, 页码 750-758出版社
WILEY
DOI: 10.1038/embor.2012.88
关键词
beta-catenin; protein complex; Kindlins; Wnt signalling
资金
- National Natural Science Foundation of China [30830048]
- Ministry of Science and Technology of China [2010CB912203, 2010CB529402]
- NSFC [31170711, 81101495]
- Beijing Natural Science Foundation [7120002]
- Swedish Cancer Foundation
- Swedish Research Council
Kindlin 2, as a focal adhesion protein, controls integrin activation. However, the association of Kindlin 2 with cancer-related signalling pathways is unknown. Here we identified a new direct interaction between Kindlin 2 and the active beta-catenin. Importantly, Kindlin 2 forms a tripartite complex with beta-catenin and TCF4. Mechanistically, Kindlin 2 selectively strengthens the occupancy of beta-catenin on the Wnt target gene Axin2 and enhances Axin2 gene expression. Functionally, the beta-catenin-Axin2-Snail cascade is required for Kindlin 2-induced tumour cell invasion. Our data indicate that Kindlin 2 is a new regulator of Wnt signalling, providing a mechanistic insight into the role of Kindlin 2 in cancer progression.
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