期刊
EMBO REPORTS
卷 13, 期 11, 页码 971-983出版社
WILEY
DOI: 10.1038/embor.2012.145
关键词
IncRNA; cell differentiation; pluripotency
资金
- National Institutes of Health [2R01 DK0467618, 2 P01 HL032262, R01 DK068348]
Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding-RNAs contribute to the regulation of mammalian development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据