期刊
EMBO REPORTS
卷 13, 期 10, 页码 923-929出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2012.119
关键词
R-loops; Saccharomyces cerevisiae; Caenorhabditis elegans; meiotic replication; genome instability
资金
- Spanish Ministry of Science and Innovation [BFU2006-05260, BFU2010-16372]
- Spanish Ministry of Science and Innovation (Consolider Ingenio) [CSD2007-0015]
- European Union (FEDER)
- Junta de Andalucia [BIO102, CVI4567]
R-loops are harmful structures with a negative impact on transcription and recombination during mitosis, but no information exists for meiosis. We used Saccharomyces cerevisiae and Caenorhabditis elegans THO mutants as a tool to determine the consequences of R-loops in meiosis. We found that both S. cerevisiae and C. elegans THO mutants show defective meiosis and an impairment of premeiotic replication as well as DNA-damage accumulation. Importantly, RNase H partially suppressed the replication impairment and the DNA-damage accumulation. We conclude that R-loops can form during meiosis causing replication impairment with deleterious results.
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