期刊
EMBO REPORTS
卷 12, 期 3, 页码 267-275出版社
WILEY
DOI: 10.1038/embor.2011.2
关键词
cohesin; meiosis; chromosome segregation; homologue synapsis; centromere
资金
- The Uehara Memorial Foundation
- The Sumitomo Foundation
- Global Center of Excellence (COE) Program
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [21000010] Funding Source: KAKEN
We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway.
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