期刊
EMBO REPORTS
卷 12, 期 11, 页码 1189-1195出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2011.188
关键词
cohesin; acetylation; meiosis; chromosome segregation
资金
- Japan Society for the Promotion of Science
- Special Coordination Funds for Promoting Science and Technology
- Global COE Program
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [23125502, 10J09396, 21000010] Funding Source: KAKEN
In fission yeast, meiotic mono-orientation of sister kinetochores is established by cohesion at the core centromere, which is established by a meiotic cohesin complex and the kinetochore protein Moa1. The cohesin subunit Psm3 is acetylated by Eso1 and deacetylated by Clr6. We show that in meiosis, Eso1 is required for establishing core centromere cohesion during S phase, whereas Moa1 is required for maintaining this cohesion after S phase. The clr6-1 mutation suppresses the mono-orientation defect of moa1 Delta cells, although the Clr6 target for this suppression is not Psm3. Thus, several acetylations are crucial for establishing and maintaining core centromere cohesion.
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