期刊
EMBO REPORTS
卷 12, 期 7, 页码 647-656出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2011.110
关键词
DNA methyltransferases; DNA methylation; PTM; non-coding RNAs
资金
- Brussels Region programme 'BruBreast'
- European Union
- Belgian Fonds de la Recherche Scientifique
DNA methyltransferases (DNMTs) establish and maintain DNA methylation patterns at specific regions of the genome, thereby contributing to gene regulation. It is becoming evident that an intricate web of pathways target DNMTs to these genomic regions. Here, we review the understanding of these regulatory mechanisms and provide an overview of the new findings, emphasizing the emerging scenario in which several levels of regulation are coordinated to control DNMTs. The mechanisms involved include the dynamic interplay between interdependent post-translational modifications that regulate DNMTs, post-transcriptional regulation by miRNAs and the emerging role of non-coding RNA in targeting mammalian DNMTs. The analysis of these mechanisms is imperative to the understanding of the role of DNA methylation in regulating gene expression during development and in disease.
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