期刊
EMBO REPORTS
卷 11, 期 9, 页码 678-684出版社
WILEY
DOI: 10.1038/embor.2010.115
关键词
mitochondria; fusion/fission; T cell; migration; adaptive/innate immunity
资金
- Swiss National Foundation [31-118171]
- OncoSuisse
- Telethon Italy
- Roche Foundation
- FP7-PEOPLE-IEF-2008 grant [235595]
Mitochondria are highly dynamic organelles, the location, size and distribution of which are controlled by a family of proteins that modulate mitochondrial fusion and fission. Recent evidence indicates that mitochondrial morphology is crucial for cell physiology, as changes in mitochondrial shape have been linked to neuro-degeneration, calcium signalling, lifespan and cell death. Because immune cells contain few mitochondria, these organelles have been considered to have only a marginal role in this physiological context-which is conversely well characterized from the point of view of signalling. Nevertheless, accumulating evidence shows that mitochondrial dynamics have an impact on the migration and activation of immune cells and on the innate immune response. Here, we discuss the roles of mitochondrial dynamics in cell pathophysiology and consider how studying dynamics in the context of the immune system could increase our knowledge about the role of dynamics in key signalling cascades.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据