期刊
EMBO REPORTS
卷 11, 期 5, 页码 380-386出版社
WILEY
DOI: 10.1038/embor.2010.44
关键词
Ago2; microRNA; CBP80/20; eIF4E; NMD
资金
- Ministry for Health, Welfare and Family affairs, Republic of Korea [0820090]
- Rural Development Administration, Republic of Korea [PJ007050]
- Korea government (MEST) [2009-0078061]
- Seoul Science Fellowship
- Korea Health Promotion Institute [0820090] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2009-0078061] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Imperfect base-pairing between microRNA (miRNA) and the 30-untranslated region of target messenger RNA (mRNA) triggers translational repression of the target mRNA. Here, we provide evidence that human Argonaute 2 targets cap-binding protein (CBP) 80/20-bound mRNAs and exon junction complex-bound mRNAs and inhibits nonsense-mediated mRNA decay (NMD), which is restricted tightly to CBP80/20-bound mRNAs. Furthermore, microarray analyses reveal that a subset of cellular transcripts, which are expected to be targeted for NMD, is stabilized by miRNA-mediated gene silencing. The regulation of NMD by miRNAs will shed light on a new post-transcriptional regulation mechanism of gene expression in mammalian cells.
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