期刊
EMBO REPORTS
卷 10, 期 12, 页码 1314-1319出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2009.243
关键词
inflammation; signal transduction; carcinogenesis; myeloid cells
资金
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Bundesministerium fur Bildung und Forschung
Our understanding of the molecular mechanisms that link inflammation and cancer has significantly increased in recent years. Here, we analyse genetic evidence indicating that the transcription factors nuclear factor-kappa B (NF-kappa B) and signal transducer and activator of transcription 3 (STAT3) have a central role in this context by regulating distinct functions in cancer cells and surrounding non-tumorigenic cells. In immune cells, NF-kappa B induces the transcription of genes that encode pro-inflammatory cytokines, which can act in a paracrine manner on initiated cells. By contrast, in tumorigenic cells, both NF-kappa B and STAT3 control apoptosis, and STAT3 can also enhance proliferation. Consequently, inflammation should be considered as a valuable target for cancer prevention and therapy.
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