期刊
EMBO REPORTS
卷 10, 期 4, 页码 400-405出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2009.9
关键词
breast cancer; metastasis; miR-29a; miRNA; tristetraprolin
资金
- GEN-AU (Genomic Research in Austria)
- FWF (Fonds zur Forderung der wissenschaftlichen Forschung) [P20115-B11]
- Austrian Science Fund (FWF) [W1207] Funding Source: Austrian Science Fund (FWF)
Several microRNAs ( miRNAs) have recently been described as crucial regulators of epithelial-to-mesenchymal transition (EMT) and metastasis. By comparing the expression profiles of miRNAs, we found upregulation of miR-29a in mesenchymal, metastatic RasXT cells relative to epithelial EpRas cells. Overexpression of miR-29a suppressed the expression of tristetraprolin (TTP), a protein involved in the degradation of messenger RNAs with AU-rich 3'-untranslated regions, and led to EMT and metastasis in cooperation with oncogenic Ras signalling. We also observed enhanced miR-29a and reduced TTP levels in breast cancer patient samples, indicating relevance for human disease. Previously, miR-29 family members were shown to have tumour-suppressive effects in haematopoietic, cholangiocytic and lung tumours. Therefore, miRNAs can act as either oncogenes or tumour suppressors, depending on the context.
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