期刊
EMBO REPORTS
卷 9, 期 3, 页码 260-266出版社
WILEY
DOI: 10.1038/embor.2008.8
关键词
polycomb group; Trithorax group; ATPase; transcriptional regulation; epigenetics
资金
- NCI NIH HHS [P30 CA023108, R01 CA055248] Funding Source: Medline
- NCRR NIH HHS [P41 RR011823] Funding Source: Medline
Pontin (Pont) and Reptin (Rept) are paralogous ATPases that are evolutionarily conserved from yeast to human. They are recruited in multiprotein complexes that function in various aspects of DNA metabolism. They are essential for viability and have antagonistic roles in tissue growth, cell signalling and regulation of the tumour metastasis suppressor gene, KAI1, indicating that the balance of Pont and Rept regulates epigenetic programmes critical for development and cancer progression. Here, we describe Pont and Rept as antagonistic mediators of Drosophila Hox gene transcription, functioning with Polycomb group (PcG) and Trithorax group proteins to maintain correct patterns of expression. We show that Rept is a component of the PRC1 PcG complex, whereas Pont purifies with the Brahma complex. Furthermore, the enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output.
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