期刊
EMBO REPORTS
卷 9, 期 7, 页码 690-697出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2008.89
关键词
acid sensation; off-response; PKD1L3; PKD2L1
资金
- NIDCD NIH HHS [R21 DC008967, DC 008967, R01 DC005782, DC05782] Funding Source: Medline
Ligand-gated ion channels are important in sensory and synaptic transduction. The PKD1L3-PKD2L1 channel complex is a sour taste receptor candidate that is activated by acids. Here, we report that the proton-activated PKD1L3-PKD2L1 ion channels have the unique ability to be activated after the removal of an acid stimulus. We refer to this property as the off-response (previously described as a delayed response). Electrophysiological analyses show that acid-induced responses are observed only after the removal of an acid solution at less than pH 3.0. A small increase in pH is sufficient for PKD1L3-PKD2L1 channel activation, after exposure to an acid at pH 2.5. These results indicate that this channel is a new type of ion channel-designated as an 'off-channel'-which is activated during stimulus application but not gated open until the removal of the stimulus. The off-response property of PKD1L3-PKD2L1 channels might explain the physiological phenomena occurring during sour taste sensation.
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