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Yun Zhao et al.
NATURE (2007)
Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling
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Requiation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
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Evidence for a novel feedback loop in the hedgehog pathway involving smoothened and fused
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Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation
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The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
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Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling
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Pathways of signal transduction employed by vertebrate Hedgehogs
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The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway
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DEVELOPMENTAL BIOLOGY (2007)
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
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DEVELOPMENTAL CELL (2006)
Modulation of the suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs
F Dussillol-Godar et al.
DEVELOPMENTAL BIOLOGY (2006)
CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling
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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
M Varjosalo et al.
DEVELOPMENTAL CELL (2006)
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
D Huangfu et al.
DEVELOPMENT (2006)
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway
K Nybakken et al.
NATURE GENETICS (2005)
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
WS Zhang et al.
DEVELOPMENTAL CELL (2005)
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
SY Tay et al.
DEVELOPMENT (2005)
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
S Apionishev et al.
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Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
GL Wang et al.
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Extensive phosphorylation of Smoothened in Hedgehog pathway activation
C Zhang et al.
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Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
W Chen et al.
SCIENCE (2004)
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
JH Jia et al.
NATURE (2004)
An intramolecular association between two domains of the protein kinase fused is necessary for hedgehog signaling
M Ascano et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
Y Nakano et al.
MECHANISMS OF DEVELOPMENT (2004)
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
L Ruel et al.
NATURE CELL BIOLOGY (2003)
Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo
C Wolff et al.
CURRENT BIOLOGY (2003)
Hedgehog signal transduction via smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
L Lum et al.
MOLECULAR CELL (2003)
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
JH Jia et al.
GENES & DEVELOPMENT (2003)
Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused
KE Nybakken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
JH Jia et al.
NATURE (2002)
Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by glycogen synthase kinase 3 and casein kinase 1
MA Price et al.
CELL (2002)
The carboxyl-terminal domain of the protein kinase fused can function as a dominant inhibitor of hedgehog signaling
M Ascano et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells
T Fukumoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Genetic dissection of the drosophila Cubitus interruptus signaling complex
MA Lefers et al.
DEVELOPMENTAL BIOLOGY (2001)
Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
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GENES & DEVELOPMENT (2000)
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
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