期刊
EMBO REPORTS
卷 9, 期 3, 页码 280-286出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/embor.2008.10
关键词
NEDD8; proteomics; proteasome; ribosomal proteins
资金
- Biotechnology and Biological Sciences Research Council [BBS/B/11974/2] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/B/11974/2] Funding Source: Medline
Identification of the molecular targets for post-translational modifications is an important step for explaining the regulated pathways. The ubiquitin-like molecule NEDD8 is implicated in the regulation of cell proliferation, viability and development. By combining proteomics and in vivo NEDDylation assays, we identified a subset of ribosomal proteins as novel targets for the NEDD8 pathway. We further show that the lack of NEDDylation in cells causes ribosomal protein instability. Our studies identify a novel and specific role of the NEDD8 pathway in protecting a subset of ribosomal proteins from destabilization.
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