期刊
EMBO MOLECULAR MEDICINE
卷 1, 期 3, 页码 152-165出版社
WILEY
DOI: 10.1002/emmm.200900024
关键词
calcium signalling; mitochondria; oxidative stress; PINK1
资金
- Medical Research Council [G0700183] Funding Source: Medline
- MRC [G0700183] Funding Source: UKRI
- Medical Research Council [G0700183] Funding Source: researchfish
The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the pink1 gene in familial PD cases firmly re-ignited interest in the pathophysiology of mitochondria in PD. PINK1 is a putative mitochondrial serine/threonine kinase, which protects cells against oxidative stress induced apoptosis. The mechanism by which this is achieved and the effect of the pathogenic mutations has been an area of intensive research over the past five years. Significant progress has been made and, in this review, we summarize the physiological roles that have been assigned to PINK1 and the potential mechanisms behind pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据