期刊
EMBO JOURNAL
卷 31, 期 12, 页码 2798-2809出版社
WILEY
DOI: 10.1038/emboj.2012.108
关键词
gene regulation; network evolution; new gene origination
资金
- US National Science Foundation awards [NSFCAREER MCB0238168, MCB1051826]
- US National Institutes of Health R01 grants [R01GM065429-01A1, 1R01GM078070-01A1]
- Packard Fellowship for Science and Engineering
- NSF Doctoral Dissertation Improvement Grant [DEB-1110607]
- NIH Genetics and Regulation Training Grant [T32 GM007197]
- Department of Education Evolutionary Genomics GAANN fellowship
- NIH grant [1P50GM081892]
- Chicago Biomedical Consortium Searle Funds at the Chicago Community Trust
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1051826] Funding Source: National Science Foundation
New genes originate frequently across diverse taxa. Given that genetic networks are typically comprised of robust, co-evolved interactions, the emergence of new genes raises an intriguing question: how do new genes interact with pre-existing genes? Here, we show that a recently originated gene rapidly evolved new gene networks and impacted sex-biased gene expression in Drosophila. This 4-6 million-year-old factor, named Zeus for its role in male fecundity, originated through retroposition of a highly conserved housekeeping gene, Caf40. Zeus acquired male reproductive organ expression patterns and phenotypes. Comparative expression profiling of mutants and closely related species revealed that Zeus has recruited a new set of downstream genes, and shaped the evolution of gene expression in germline. Comparative ChIP-chip revealed that the genomic binding profile of Zeus diverged rapidly from Caf40. These data demonstrate, for the first time, how a new gene quickly evolved novel networks governing essential biological processes at the genomic level. The EMBO Journal (2012) 31, 2798-2809. doi:10.1038/emboj.2012.108; Published online 27 April 2012
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