期刊
EMBO JOURNAL
卷 30, 期 10, 页码 1990-2007出版社
WILEY
DOI: 10.1038/emboj.2011.102
关键词
extravasation; melanoma; miR-214; TFAP2C; tumour progression
资金
- University of Torino [2007/DT, 2008/DT]
- Regione Piemonte Ricerca Scientifica Applicata [CIPE2004/DT]
- Compagnia di San Paolo
- Torino
- AIRC [IG 10104]
- FIRB [RBFR08F2FS-002 FO]
Malignant melanoma is fatal in its metastatic stage. It is therefore essential to unravel the molecular mechanisms that govern disease progression to metastasis. MicroRNAs (miRs) are endogenous non-coding RNAs involved in tumourigenesis. Using a melanoma progression model, we identified a novel pathway controlled by miR-214 that co-ordinates metastatic capability. Pathway components include TFAP2C, homologue of a well-established melanoma tumour suppressor, the adhesion receptor ITGA3 and multiple surface molecules. Modulation of miR-214 influences in vitro tumour cell movement and survival to anoikis as well as extravasation from blood vessels and lung metastasis formation in vivo. Considering that miR-214 is known to be highly expressed in human melanomas, our data suggest a critical role for this miRNA in disease progression and the establishment of distant metastases. The EMBO Journal (2011) 30, 1990-2007. doi: 10.1038/emboj.2011.102; Published online 5 April 2011
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