期刊
EMBO JOURNAL
卷 30, 期 17, 页码 3540-3552出版社
WILEY
DOI: 10.1038/emboj.2011.278
关键词
dendritic RNA transport; neuronal RNA granule; RNA-binding proteins; RNA signature; synaptic tagging and capture
资金
- FWF [SFB F4314-B09, P-20583-B12]
- HFSP
- ESF RNA quality control [FWF I127-B12]
- Austrian Science Fund (FWF) [W1207] Funding Source: Austrian Science Fund (FWF)
The localization of RNAs critically contributes to many important cellular processes in an organism, such as the establishment of polarity, asymmetric division and migration during development. Moreover, in the central nervous system, the local translation of mRNAs is thought to induce plastic changes that occur at synapses triggered by learning and memory. Here, we will critically review the physiological functions of well-established dendritically localized mRNAs and their associated factors, which together form ribonucleoprotein particles (RNPs). Second, we will discuss the life of a localized transcript from transcription in the nucleus to translation at the synapse and introduce the concept of the 'RNA signature' that is characteristic for each transcript. Finally, we present the 'sushi belt model' of how localized RNAs within neuronal RNPs may dynamically patrol multiple synapses rather than being anchored at a single synapse. This new model integrates our current understanding of synaptic function ranging from synaptic tagging and capture to functional and structural reorganization of the synapse upon learning and memory. The EMBO Journal (2011) 30, 3540-3552. doi:10.1038/emboj.2011.278
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