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A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels
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A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel
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NATURE COMMUNICATIONS (2014)
Recovery of Current through Mutated TASK3 Potassium Channels Underlying Birk Barel Syndrome
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Silencing of the Tandem Pore Domain Halothane-inhibited K+ Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane
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Endothelial TWIK-related potassium channel-1 (TREK 1) regulates immune-cell trafficking into the CNS
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Altered Expression of Two-Pore Domain Potassium (K2P) Channels in Cancer
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PLOS ONE (2013)
G protein modulation of K2P potassium channel TASK-2
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PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2013)
The contribution of TWIK-1 channels to astrocyte K+ current is limited by retention inintracellular compartments
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Direct Inhibitory Effect of Fluoxetine on TREK-2 Channel
Dawon Kang et al.
BIOPHYSICAL JOURNAL (2012)
PKC-dependent activation of human K2P18.1 K+ channels
Ann-Kathrin Rahm et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation
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TASK-3 Channel Deletion in Mice Recapitulates Low-Renin Essential Hypertension
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Acid-sensitive TWIK and TASK Two-pore Domain Potassium Channels Change Ion Selectivity and Become Permeable to Sodium in Extracellular Acidification
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
TRESK: The lone ranger of two-pore domain potassium channels
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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Spadin as a new antidepressant: Absence of TREK-1-related side effects
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NEUROPHARMACOLOGY (2012)
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PLOS ONE (2012)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel
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SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons
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SCIENCE SIGNALING (2012)
Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability
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BASIC RESEARCH IN CARDIOLOGY (2011)
Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
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Knock-Out of the Potassium Channel TASK-1 Leads to a Prolonged QT Interval and a Disturbed QRS Complex
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CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2011)
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Disruption of K2P6.1 Produces Vascular Dysfunction and Hypertension in Mice
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The Two-Pore Domain Potassium Channel KCNK5: Induction by Estrogen Receptor α and Role in Proliferation of Breast Cancer Cells
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TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury
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Gating of two pore domain potassium channels
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A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura
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Task2 potassium channels set central respiratory CO2 and O2 sensitivity
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TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
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The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
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Deletion of TASK1 and TASK3 channels disrupts intrinsic excitability but does not abolish glucose or pH responses of orexin/hypocretin neurons
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JOURNAL OF MOLECULAR BIOLOGY (2009)
Glucose Inhibition Persists in Hypothalamic Neurons Lacking Tandem-Pore K+ Channels
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Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells
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Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue
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Maternally inherited Birk barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9
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Knockout of the gene encoding the K2P channel KCNK7 does not alter volatile anesthetic sensitivity
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Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels
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Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium
Dierk Thomas et al.
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TASK channel deletion in mice causes primary hyperaldosteronism
Lucinda A. Davies et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact
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Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
Dirk Heitzmann et al.
EMBO JOURNAL (2008)
TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity
Daniel K. Mulkey et al.
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TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones
Tina Dobler et al.
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TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation Anesthetics
Anni-Maija Linden et al.
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Properties of single two-pore domain TREK-2 channels expressed in mammalian cells
Dawon Kang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Does sumoylation control K2P1/TWIK1 background K+ channels?
Sylvain Feliciangeli et al.
CELL (2007)
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Nicolas Blondeau et al.
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Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney
S. L'Hoste et al.
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Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel
Maria Isabel Niemeyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link
Ambroise Garry et al.
EMBO REPORTS (2007)
AKAP150, a switch to convert mechano-, pH- and arachidonic acid- sensitive TREK K+ channels into open leak channels
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EMBO JOURNAL (2006)
Gating of two-pore domain K+ channels by extracellular pH
M. I. Niemeyer et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice
I. D. Millar et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2006)
Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor
Dawon Kang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2006)
Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype
Catherine Heurteaux et al.
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Interaction between the cellular prion (PrPC) and the 2P domain K+ channel TREK-1 protein
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TREK-1, a K+ channel involved in polymodal pain perception
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Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
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The in vivo contributions of TASK-1-containing channels to the actions of inhalation anesthetics, the α2 adrenergic sedative dexmedetomidine, and cannabinoid agonists
AM Linden et al.
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Biophysical and pharmacological characteristics of native two-pore domain TASK channels in rat adrenal glomerulosa cells
David P. Lotshaw
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Inhibition of a background potassium channel by Gq protein α-subunits
XD Chen et al.
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The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1
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TRAFFIC (2006)
The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle
XT Li et al.
CARDIOVASCULAR RESEARCH (2006)
Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons
MI Aller et al.
JOURNAL OF NEUROSCIENCE (2005)
International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels
AD Wei et al.
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X Nie et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2005)
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International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
GA Gutman et al.
PHARMACOLOGICAL REVIEWS (2005)
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels
SAN Goldstein et al.
PHARMACOLOGICAL REVIEWS (2005)
Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels
J Murbartián et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton
I Lauritzen et al.
EMBO REPORTS (2005)
Sumoylation silences the plasma membrane leak K+ channel K2P1
S Rajan et al.
CELL (2005)
PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels
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JOURNAL OF PHYSIOLOGY-LONDON (2005)
Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK
D Kang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine
LE Kennard et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species
F Duprat et al.
JOURNAL OF PHYSIOLOGY-LONDON (2005)
O-2 sensing by recombinant twik-related halothane-inhibitable K+ channel-1 background K+ channels heterologously expressed in human embryonic kidney cells
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NEUROSCIENCE (2005)
The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin
B Czirják et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family
DW Kang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK-1 (KCNK3) and TASK-3 (KCNK9) subunits
AP Berg et al.
JOURNAL OF NEUROSCIENCE (2004)
TREK-1, a K+ channel involved in neuroprotection and general anesthesia
C Heurteaux et al.
EMBO JOURNAL (2004)
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics
CH Liu et al.
ANESTHESIA AND ANALGESIA (2004)
TREK-1 K+ channels couple angiotensin II receptors to membrane depolarization and aldosterone secretion in bovine adrenal glomerulosa cells
JA Enyeart et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6
S Decressac et al.
EMBO REPORTS (2004)
Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: a role for O-2 in the control of neuronal excitability?
PJ Kemp et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2004)
Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport
R Warth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells
AM Gurney et al.
CIRCULATION RESEARCH (2003)
K+-dependent cerebellar granule neuron apoptosis -: Role of task leak K+ channels
I Lauritzen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules
H Barriere et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF
P Fong et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord
Y Sano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function
L Pei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mutation of KCNK5 or kir3.2 potassium channels in mice does not change minimum alveolar anesthetic concentration
KM Gerstin et al.
ANESTHESIA AND ANALGESIA (2003)
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene
D Mu et al.
CANCER CELL (2003)
Determinants of pH sensing in the two-pore domain K+ channels TASK-1 and-2
MJ Morton et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2003)
Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals
I O'Kelly et al.
CELL (2002)
p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1
C Girard et al.
EMBO JOURNAL (2002)
An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1
E Honoré et al.
EMBO JOURNAL (2002)
Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human two-pore K+ channel gene KCNK4 -: Chromosomal localization, tissue distribution and functional expression
A Ozaita et al.
MOLECULAR BRAIN RESEARCH (2002)
Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels - Volatile anesthetics and neurotransmitters share a molecular site of action
EM Talley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2
WL Gu et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits
G Czirják et al.
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TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase - An essential role in smooth muscle inhibitory neurotransmission
SD Koh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
TASK-5, a novel member of the tandem pore K+ channel family
I Ashmole et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi
Y Kim et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Combined antisense and pharmacological approaches implicate hTASK as an airway O2 sensing K+ channel
ME Hartness et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
TASK-5, a new member of the tandem-pore K+ channel family
D Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Synergistic interaction and the rose of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali
Y Kim et al.
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Genomic and functional characteristics of novel human pancreatic 2P domain K+ channels
C Girard et al.
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THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels
S Rajan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel
HJ Meadows et al.
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Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
SG Brickley et al.
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TWIK-2, an inactivating 2P domain K+ channel
AJ Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors
F Lesage et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family
H Bang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3
CMB Lopes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
TASK-3, a novel tandem pore domain acid-sensitive K+ channel -: An extracellular histidine as pH sensor
S Rajan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
TREK-1 is a heat-activated background K+ channel
F Maingret et al.
EMBO JOURNAL (2000)
An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells
KJ Buckler et al.
JOURNAL OF PHYSIOLOGY-LONDON (2000)
Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K+ channel
F Lesage et al.
FEBS LETTERS (2000)
Lysophospholipids open the two-pore domain mechano-gated K+ channels TREK-1 and TRAAK
F Maingret et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
TASK-3, a new member of the tandem pore K+ channel family
Y Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)