相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia
Nicholas C. Wolff et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Lysosomal positioning coordinates cellular nutrient responses
Viktor I. Korolchuk et al.
NATURE CELL BIOLOGY (2011)
Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
B. Kucejova et al.
ONCOGENE (2011)
Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation
Yueguang Rong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
Yonghao Yu et al.
SCIENCE (2011)
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Masako Narita et al.
SCIENCE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Structural Analysis and Functional Implications of the Negative mTORCl Regulator REDD1
Silvia Vega-Rubin-de-Celis et al.
BIOCHEMISTRY (2010)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
Regulation of mTORC1 by the Rab and Arf GTPases
Li Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Late Endosome is Essential for mTORC1 Signaling
Rory J. Flinn et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
Termination of autophagy and reformation of lysosomes regulated by mTOR
Li Yu et al.
NATURE (2010)
Amino acid regulation of TOR complex 1
Joseph Avruch et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Regulation Mechanisms and Signaling Pathways of Autophagy
Congcong He et al.
ANNUAL REVIEW OF GENETICS (2009)
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Nahum Sonenberg et al.
CELL (2009)
Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas
G. Martignoni et al.
MODERN PATHOLOGY (2009)
Uncommon and recently described renal carcinomas
John R. Srigley et al.
MODERN PATHOLOGY (2009)
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
Xiaobo Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions
Viveka Mayya et al.
SCIENCE SIGNALING (2009)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
The V-type H+-ATPase in vesicular trafficking:: targeting, regulation and function
Vladimir Marshansky et al.
CURRENT OPINION IN CELL BIOLOGY (2008)
Mammalian target of rapamycin as a therapeutic target in oncology
Robert T. Abraham et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2008)
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
Maurice Phillip DeYoung et al.
GENES & DEVELOPMENT (2008)
Efficacy of everolimus in advanced renal cell carcinoma:: a double-blind, randomised, placebo-controlled phase III trial
Robert J. Motzer et al.
LANCET (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
A quantitative atlas of mitotic phosphorylation
Noah Dephoure et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
PEComas: the past, the present and the future
Guido Martignoni et al.
VIRCHOWS ARCHIV (2008)
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
William G. Kaelin
NATURE REVIEWS CANCER (2008)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Michoel Forgac
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms
Heidi Kenerson et al.
HUMAN PATHOLOGY (2007)
Pathways of clathrin-independent endocytosis
Satyajit Mayor et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
Gary Hudes et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma
S. Maureen Nemetski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth
Krista M. Hennig et al.
JOURNAL OF CELL BIOLOGY (2006)
Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
Eileen Connolly et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Hypoxia-induced energy stress regulates mRNA translation and cell growth
LP Liu et al.
MOLECULAR CELL (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
The V-type H+ ATPase:: molecular structure and function, physiological roles and regulation
KW Beyenbach et al.
JOURNAL OF EXPERIMENTAL BIOLOGY (2006)
Regulation of the small GTPase Rheb by amino acids
M Roccio et al.
ONCOGENE (2006)
Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions
F Kaper et al.
CANCER RESEARCH (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
L Pelkmans et al.
NATURE (2005)
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
EM Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
DC Fingar et al.
ONCOGENE (2004)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
J Brugarolas et al.
GENES & DEVELOPMENT (2004)
The LKB1 tumor suppressor negatively regulates mTOR signaling
RJ Shaw et al.
CANCER CELL (2004)
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
MN Corradetti et al.
GENES & DEVELOPMENT (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder et al.
NATURE MEDICINE (2004)
Melanocytes and the Microphthalmia transcription factor network
E Steingrimsson et al.
ANNUAL REVIEW OF GENETICS (2004)
TSC2 mediates cellular energy response to control cell growth and survival
K Inoki et al.
CELL (2003)
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
AF Castro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee et al.
CURRENT BIOLOGY (2003)
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
JB Brugarolas et al.
CANCER CELL (2003)
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
K Inoki et al.
GENES & DEVELOPMENT (2003)
Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution
RP Kuiper et al.
HUMAN MOLECULAR GENETICS (2003)
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
Y Zhang et al.
NATURE CELL BIOLOGY (2003)
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
A Garami et al.
MOLECULAR CELL (2003)
Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation
IJ Davis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
N El-Hashemite et al.
LANCET (2003)
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
A Jaeschke et al.
JOURNAL OF CELL BIOLOGY (2002)
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
HC Dan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
R Loewith et al.
MOLECULAR CELL (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Mutations in subunit c of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site
BJ Bowman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
DJ Kwiatkowski et al.
HUMAN MOLECULAR GENETICS (2002)