期刊
EMBO JOURNAL
卷 31, 期 2, 页码 471-480出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2011.402
关键词
ASPP1; LATS2; p21; p53; YAP
资金
- Cancer Research UK
In addition to acting as a transcriptional cofactor for p53, ASPP1 has been shown to function in the cytoplasm to regulate the nuclear localization and activity of YAP/TAZ. We show here that the ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability of p53 to induce p21, cell-cycle arrest and senescence. ASPP1 expression peaks in S-phase, and down-regulation of ASPP1 leads to a reduction in DNA synthesis and enhanced senescence in response to drugs that impede DNA replication. These activities of cytoplasmic ASPP1 in opposing p53-mediated p21 expression are in contrast to the role of nuclear ASPP1 in cooperating with p53 to induce the expression of apoptotic target genes, and may help to dampen p53 activity in normal cells. The EMBO Journal (2012) 31, 471-480. doi:10.1038/emboj.2011.402; Published online 8 November 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据