期刊
EMBO JOURNAL
卷 30, 期 6, 页码 988-990出版社
WILEY
DOI: 10.1038/emboj.2011.47
关键词
-
资金
- NIAID NIH HHS [P01 AI044220] Funding Source: Medline
NF-kappa B-dependent immune responses are tightly controlled so as to avoid runaway inflammation. One easy model to study the negative regulation of these pathways is provided by the Drosophila melanogaster immune deficiency (IMD) pathway, which regulates both systemic and epithelial immune responses against bacteria. Ragab et al (2011) report in this issue of the EMBO Journal that the Ras/MAPK pathway negatively regulates the IMD pathway when activated by the PDGF/VEGF receptor (PVR), a process mediated by the PIRK/Rudra/PIMS inhibitor. This study raises interesting questions regarding the biological significance of IMD negative regulation in diverse settings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据