期刊
EMBO JOURNAL
卷 29, 期 17, 页码 2864-2874出版社
WILEY
DOI: 10.1038/emboj.2010.165
关键词
checkpoint; double-strand break; meiosis; nucleases; telomere
资金
- Associazione Italiana per la Ricerca sul Cancro [IG5636]
- Cofinanziamento 2008 MIUR/Universita di Milano-Bicocca
- Fondazione Italiana per la Ricerca sul Cancro
DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because failure to repair these lesions can lead to genomic instability. DSBs can arise accidentally at unpredictable locations into the genome, but they are also normal intermediates in meiotic recombination. Moreover, the natural ends of linear chromosomes resemble DSBs. Although intrachromosomal DNA breaks are potent stimulators of the DNA damage response, the natural ends of linear chromosomes are packaged into protective structures called telomeres that suppress DNA repair/recombination activities. Although DSBs and telomeres are functionally different, they both undergo 5'-3' nucleolytic degradation of DNA ends, a process known as resection. The resulting 3'-single-stranded DNA overhangs enable repair of DSBs by homologous recombination (HR), whereas they allow the action of telomerase at telomeres. The molecular activities required for DSB and telomere end resection are similar, indicating that the initial steps of HR and telomerase-mediated elongation are related. Resection of both DSBs and telomeres must be tightly regulated in time and space to ensure genome stability and cell survival. The EMBO Journal (2010) 29, 2864-2874. doi: 10.1038/emboj.2010.165; Published online 20 July 2010
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