期刊
EMBO JOURNAL
卷 29, 期 18, 页码 3130-3139出版社
WILEY
DOI: 10.1038/emboj.2010.188
关键词
cell cycle; CHD4; chromatin remodelling; DNA damage; DNA repair
资金
- Cancer Research UK
- European Union [LSHG-CT-2005-512113, HEALTH-F2-2007-201630]
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council
- Human Frontier Science Program Organization
- Herchel Smith Postdoctoral Research Fellowship
- Cancer Research UK [11224] Funding Source: researchfish
The chromatin remodelling factor chromodomain helicase DNA-binding protein 4 (CHD4) is a catalytic subunit of the NuRD transcriptional repressor complex. Here, we reveal novel functions for CHD4 in the DNA-damage response (DDR) and cell-cycle control. We show that CHD4 mediates rapid poly(ADP-ribose)-dependent recruitment of the NuRD complex to DNA-damage sites, and we identify CHD4 as a phosphorylation target for the apical DDR kinase ataxia-telangiectasia mutated. Functionally, we show that CHD4 promotes repair of DNA double-strand breaks and cell survival after DNA damage. In addition, we show that CHD4 acts as an important regulator of the G1/S cell-cycle transition by controlling p53 deacetylation. These results provide new insights into how the chromatin remodelling complex NuRD contributes to maintaining genome stability.
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