期刊
EMBO JOURNAL
卷 29, 期 10, 页码 1627-1628出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2010.79
关键词
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资金
- Human Frontiers Science Program
In this issue of The EMBO Journal, Chattopadhyay et al (2010) describe a surprising new mechanism for how viral dsRNA detection by the RIG-I/MAVS signalling complex can initiate apoptosis. Independent of its transcriptional function, a pool of interferon regulatory factor (IRF)-3 activated downstream of MAVS can bind to and activate cytosolic Bax, resulting in Bax translocation to the mitochondria and initiation of the intrinsic apoptotic pathway.
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