期刊
EMBO JOURNAL
卷 29, 期 11, 页码 1889-1902出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2010.72
关键词
actin cytoskeleton; neuronal physiology; synaptic plasticity
资金
- Deutsche Forschungsgemeinschaft [RU-1232/1-1]
- Stiftung Rheinland-Pfalz [961-386261/877]
- Agence National de la Recherche [ANR08-Blan-0282]
- Fondation Pierre-Gilles de Gennes
- MIUR
- Regione Piemonte [142, 2006, 2008]
- Telethon-Italy [GGP05236A]
- Secretaria de Estado de Universidades e Investigacion, MEC [EX2006-0294]
- Compagnia di San Paolo [2007]
Neuronal plasticity is an important process for learning, memory and complex behaviour. Rapid remodelling of the actin cytoskeleton in the postsynaptic compartment is thought to have an important function for synaptic plasticity. However, the actin-binding proteins involved and the molecular mechanisms that in vivo link actin dynamics to postsynaptic physiology are not well understood. Here, we show that the actin filament depolymerizing protein n-cofilin is controlling dendritic spine morphology and postsynaptic parameters such as late long-term potentiation and long-term depression. Loss of n-cofilin-mediated synaptic actin dynamics in the fore-brain specifically leads to impairment of all types of associative learning, whereas exploratory learning is not affected. We provide evidence for a novel function of n-cofilin function in synaptic plasticity and in the control of extrasynaptic excitatory AMPA receptors diffusion. These results suggest a critical function of actin dynamics in associative learning and postsynaptic receptor availability. The EMBO Journal (2010) 29, 1889-1902. doi:10.1038/emboj.2010.72; Published online 20 April 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据