期刊
EMBO JOURNAL
卷 28, 期 9, 页码 1296-1307出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2009.76
关键词
apoptosis; cyclophilin; Drosophila; photoreceptor neuron; unfolded protein response
资金
- National Institute of Health [RO1 EY14025]
- Fondation pour la Recherche Medicale
- CNRS
- Fundacao para a Ciencia e a Tecnologia, Portugal
- HNV
The unfolded protein response (UPR) is a specific cellular process that allows the cell to cope with the overload of unfolded/misfolded proteins in the endoplasmic reticulum (ER). ER stress is commonly associated with degenerative pathologies, but its role in disease progression is still a matter for debate. Here, we found that mutations in the ER-resident chaperone, neither inactivation nor afterpotential A (NinaA), lead to mild ER stress, protecting photoreceptor neurons from various death stimuli in adult Drosophila. In addition, Drosophila S2 cultured cells, when pre-exposed to mild ER stress, are protected from H(2)O(2), cycloheximide-or ultraviolet-induced cell death. We show that a specific ER-mediated signal promotes antioxidant defences and inhibits caspase-dependent cell death. We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses. The EMBO Journal (2009) 28, 1296-1307. doi: 10.1038/emboj.2009.76; Published online 2 April 2009
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