期刊
EMBO JOURNAL
卷 29, 期 2, 页码 340-351出版社
WILEY
DOI: 10.1038/emboj.2009.328
关键词
epigenetics; MOM1; RNA-directed DNA methylation; tiling array; transcription profiling
资金
- Swiss National Science Foundation [3100A0-102107]
It is commonly observed that onset or release of transcriptional gene silencing (TGS) correlates with alteration of repressive epigenetic marks. The TGS regulator MOM1 in Arabidopsis is exceptional since it regulates transcription in intermediate heterochromatin with only minor changes in epigenetic marks. We have isolated an enhancer of the mom1 mutation that points towards regulatory interplay between MOM1 and RNA polymerase-V ( Pol-V). Pol-V transcribes heterochromatic loci, which seems to be required for maintenance of their silencing; however, it is still not clear how Pol-V is targeted to heterochromatin. We now provide evidence that Pol-V is required for MOM1-mediated suppression of transcription at a subset of its chromosomal targets. Thus, Pol-V genetically interacts with MOM1 in the control of gene silencing. Interestingly, functional cooperation of MOM1 and Pol-V not only broadens the range of the controlled loci in comparison to each individual factor, but also determines the degree of TGS. The EMBO Journal (2010) 29, 340-351. doi: 10.1038/emboj.2009.328; Published online 12 November 2009
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