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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks
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The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication
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The mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
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TopBP1 activates the ATR-ATRIP complex
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HUMAN MOLECULAR GENETICS (2005)
Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes
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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
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MOLECULAR AND CELLULAR BIOLOGY (2005)
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Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
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Replication protein A and the Mre11•Rad50•Nbs1 complex co-localize and interact at sites of stalled replication forks
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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
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The Mre11 complex is required for ATM activation and the G2/M checkpoint
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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
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Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
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Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication
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