期刊
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
卷 200, 期 -, 页码 105-113出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.aanat.2015.02.012
关键词
Human embryology; Organogenesis; 3D reconstruction; Liver; Portal system; Biliary tract; Hepatic venous system
资金
- Association des Morphologistes (AM)
- British Association of Clinical Anatomists (BACA)
- American Association of Anatomists (AAA)
Background & Aim: Some aspects of human embryogenesis and organogenesis remain unclear, especially concerning the development of the liver and its vasculature. The purpose of this study was to investigate, from a descriptive standpoint, the evolutionary morphogenesis of the human liver and its vasculature by computerized three-dimensional reconstructions of human embryos. Material & Methods: Serial histological sections of four human embryos at successive stages of development belonging to three prestigious French historical collections were digitized and reconstructed in 3D using software commonly used in medical radiology. Manual segmentation of the hepatic anatomical regions of interest was performed section by section. Results: In this study, human liver organogenesis was examined at Carnegie stages 14, 18,21 and 23. Using a descriptive and an analytical method, we showed that these stages correspond to the implementation of the large hepatic vascular patterns (the portal system, the hepatic artery and the hepatic venous system) and the biliary system. Conclusion: To our knowledge, our work is the first descriptive morphological study using 3D computerized reconstructions from serial histological sections of the embryonic development of the human liver between Carnegie stages 14 and 23. (C) 2015 Elsevier GmbH. All rights reserved.
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