期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 593, 期 5, 页码 1047-1063出版社
WILEY
DOI: 10.1113/jphysiol.2014.274712
关键词
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资金
- South-Eastern Norway Regional Health Authority
- Research Council of Norway
- Anders Jahre's Fund for the Promotion of Science
- Oslo University Hospital Ulleval
- University of Oslo
- European Union Project [FP7-HEALTH-2010.2.4.2-4]
Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca2+ sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca2+ homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as cultured neonatal cells and stem cells.
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