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Capillary electrophoresis in two-dimensional separation systems: Techniques and applications

期刊

ELECTROPHORESIS
卷 36, 期 1, 页码 144-158

出版社

WILEY
DOI: 10.1002/elps.201400368

关键词

Comprehensive; Coupling; Electromigrative techniques; Heart-cut; Orthogonality

资金

  1. Federal Ministry of Education and Research (BMBF) [FKZ 17N1110]

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The analysis of complex samples requires powerful separation techniques. Here, 2D chromatographic separation techniques (e.g. LC-LC, GC-GC) are increasingly applied in many fields. Electrophoretic separation techniques show a different selectivity in comparison to LC and GC and very high separation efficiency. Thus, 2D separation systems containing at least one CE-based separation technique are an interesting alternative featuring potentially a high degree of orthogonality. However, the generally small volumes and strong electrical fields in CE require special coupling techniques. These technical developments are reviewed in this work, discussing benefits and drawbacks of offline and online systems. Emphasis is placed on the design of the systems, their coupling, and the detector used. Moreover, the employment of strategies to improve peak capacity, resolution, or sensitivity is highlighted. Various applications of 2D separations with CE are summarized.

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