期刊
ELECTROPHORESIS
卷 31, 期 22, 页码 3675-3680出版社
WILEY
DOI: 10.1002/elps.201000331
关键词
Microfluidics; Post; Self-assembly
资金
- MRSEC Program of the National Science Foundation [DMR-0819885]
- David and Lucile Packard Foundation
- NSF though the NNIN
- Institute of Technology Characterization Facility at the University of Minnesota
- NSF
We provide an experimental test of the universal behavior arising in simulations of the electrophoretic collision of a long DNA molecule with an isolated, thin post. Our experiments take advantage of a robust protocol to embed matrices of circa 100 nm radius ZnO nanowires in a microfluidic channel. The density and height of the nanowires are easily controlled by the seeding and growth conditions. Single-molecule videomicroscopy of lambda-DNA electrophoresis in a sparse nanowire array shows that the average holdup time decays exponentially with the impact parameter, in agreement with simulations. Only at the largest electric field studied here does the hooking probability approach that for an infinitesimally thin post.
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