期刊
ELECTROPHORESIS
卷 31, 期 18, 页码 3144-3151出版社
WILEY
DOI: 10.1002/elps.201000133
关键词
Microfludics; Micropattern; Neuronal guidance; Sharp change
资金
- Ministry of Science and Technology [2006CB705600, 2007CB714502, 2009CB930001]
- National Natural Science Foundation of China [90813032, 20890020]
- Chinese Academy of Sciences [KJCX2-YW-M15]
In this report we fabricated laminin (LN) stripes on a background of poly-L-lysine as substrates for the growth of rat hippocampal neurons, and found that a sharp change of the concentration of LN guides the growth of neurites by leading the growth cones in a time- and space-dependent manner. The percentage of neurites that grow along the edge of LN stripes (where there is a sharp change of concentration) decreases as a function of the concentration of LN under a threshold value. The actin cytoskeleton plays an important role in the process of growth cone's response to the sharp change of concentration of LN on micropatterns. We believe that the findings here are useful for not only fundamental studies in neuroscience, but also helpful for the design of devices or chips for nervous prosthesis.
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