期刊
ELECTROPHORESIS
卷 30, 期 16, 页码 2820-2828出版社
WILEY
DOI: 10.1002/elps.200800852
关键词
Affinity capillary electrophoresis; Competitive binding; N-Undecenoxy-carbonyl-L-leucinol bromide; Profens; 2,3,6-Tri-O-methyl-beta-CD
资金
- National Institute Of Health [2R01-GM062314]
- Petroleum Research Fund [47774-AC7]
A competitive inhibition mechanism is proposed to investigate the interactions among 2,3,6-tri-O-methyl-beta-CD (TM-beta-CD), cationic ionic liquid type surfactants, N-undecenoxy-carbonyl-L-leucinol bromide (L-UCLB) and profens using affinity CE. The apparent binding constant of TM-beta-CD to L-UCLB was estimated by nonlinear and linear plotting methods. The binding constants of one representative profen (e.g. fenoprofen) to TM-beta-CD and L-UCLB were estimated by a secondary plotting approach. The R- and S-fenoprofens have different binding constant values, resulting in the enantioseparation due to the synergistic effect of the two chiral selectors, TM-beta-CD and L-UCLB.
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