期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 66, 期 4, 页码 327-336出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12576-015-0430-3
关键词
Cardiac myocytes; L-type Ca2+ channels; Adenylyl cyclase; Phosphodiesterase; Phosphatase; Protein kinase A
类别
资金
- East-West cooperation grant from INSERM, France
beta-adrenergic receptors (beta-ARs) mediate the positive inotropic effects of catecholamines by cAMP-dependent phosphorylation of the L-type Ca2+ channels (LTCCs), which provide Ca2+ for the initiation and regulation of cell contraction. The overall effect of cAMP-modulating agents on cardiac calcium current (I (Ca,L)) and contraction depends on the basal activity of LTCCs which, in turn, depends on the basal activities of key enzymes involved in the cAMP signaling cascade. Our current work is a comparative study demonstrating the differences in the basal activities of beta-ARs, adenylyl cyclase, phosphodiesterases, phosphatases, and LTCCs in the frog and rat ventricular and human atrial myocytes. The main conclusion is that the basal I (Ca,L), and consequently the contractile function of the heart, is secured from unnecessary elevation of its activity and energy consumption at the several checking-points of cAMP-dependent signaling cascade and the loading of these checking-points may vary in different species and tissues.
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