期刊
ELECTROCHIMICA ACTA
卷 286, 期 -, 页码 365-373出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2018.07.158
关键词
Oxidative stress; Nitric oxide; poly(eugenol); Microchannel; Electrochemical sensor
资金
- Institut Pierre Gilles de Gennes (IPGG) [ANR-10-Labx-31]
The detection of reactive oxygen and nitrogen species is of utmost importance in several pathological situations. Indeed, these reactive species are biomarkers of oxidative stress and their real-time monitoring is crucial to adapt medical treatments. We report here on the electrochemical detection of nitric oxide (NO center dot) in the presence of hydrogen peroxide (H2O2). The detection was performed by using different sensing microdevices involving either static solutions in wells or flowing solutions in microfluidic channels. Furthermore, an original strategy was proposed to further enhance the selectivity of NO center dot detection at Pt/poly(eugenol) modified platinum electrodes by designing a dual-electrode microfluidic device based on a pre-electrolysis of interfering species including H2O2 at an upstream electrode prior to NO center dot detection. (C) 2018 Elsevier Ltd. All rights reserved.
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