期刊
ELECTROCHIMICA ACTA
卷 132, 期 -, 页码 49-57出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2014.03.124
关键词
Renewable silver-amalgam film electrode; AdSWV; doxorubicin; urine; trace level determination
资金
- Ministry of Science and Technological Development of the Republic of Serbia [172012, III 45005]
Voltammetric characterization of doxorubicin (DOX) and its determination using a renewable silver-amalgam film electrode (Hg(Ag)FE) was performed by direct cathodic square-wave voltammetry (SWV) and by the highly sensitive adsorptive square-wave voltammetry (AdSWV) in aqueous Britton-Robinson buffer solutions as supporting electrolyte (pH 2.0-8.0). The Hg(Ag)FE response of DOX was monitored in the potential range between -0.20 and -0.80 V. For the trace level analysis the method optimization showed that the optimal conditions were: the pH 6.0, the accumulation potential -0.20V, and the accumulation time 140 s. In the model solutions, DOX was determined in the concentration range of 4.99-59.64 ng mL(-1). The developed AdSWV method was applied for the determination of DOX in spiked human urine sample. The lowest concentration of DOX of 9.89 ng mL(-1) was determined with the relative standard deviation less than 6%. (C) 2014 Elsevier Ltd. All rights reserved.
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