Study of the adsorption process of bovine serum albumin on passivated surfaces of CoCrMo biomedical alloy

Adsorption of bovine serum albumin (BSA) on CoCrMo surface was studied by electrochemical techniques in order to determine the mechanism of protein adsorption at different surface conditions (which are reached by considering different passivation times) in phosphate buffered solution (PBS) At open circuit potential (OCP) adsorption kinetic was influenced by surface passivation when passivation time was lower than 1 h whereas at higher passivation times no apparent modification in the kinetic mechanisms of adsorption was observed On the other hand at a passive applied potential the BSA addition decreased the passivation kinetics of the process at all the passivation times (C) 2010 Elsevier Ltd All rights reserved