期刊
ELECTROCHIMICA ACTA
卷 55, 期 7, 页码 2522-2526出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2009.12.019
关键词
Nimesulide; Multiwalled carbon nanotubes; Nafion; Modified electrode; Electrochemical behavior
资金
- Natural Science Foundation of Guangxi Zhuang Autonomous Region [0639025, 0991084]
- Support Program for 100 Young and Middle-aged Disciplinary Leaders in Guangxi Higher Education Institutions [RC20060703005]
- Key Laboratory of Development and Application of Forest Chemicals of Guangxi [GXFC08-06]
- Education Department of Guangxi Zhuang Autonomous Region [200807MS074]
- Innovation Project of Guangxi University for Nationalities [gxun-chx2009081]
A new method for the determination of nimesulide was established based on the multiwalled carbon nanotubes (MWCNTs) modified glassy carbon electrode (MWCNTs/GCE). In 0.2 M PBS (pH 6.6) buffer solution, the MWCNTs/GCE showed a remarkable catalytic and enhancement effect on reduction of the nimesulide. The reduction peak potential of nimesulide shifted positively from -0.665 V at bare GCE to -0.553 V at MWCNTs/GCE, and the sensitivity increased ca. 7 times. A linear dynamic range of 3.2 x 10(-7) -6.5 x 10(-5) M (R = 0.9992) with a detection limit of 1.6 x 10(-7) M was obtained. The electrochemical behaviors of nimesulide were studied and electron-transfer coefficient (alpha = 0.45), proton number(X = 1)and electron-transfer number (n = 2) have been determined. This method has been used to determine the content of nimesulide in medical tablets. The recovery was determined to be 93.2-106.2% by means of standard addition method. Compared with UV-vis spectrometry, the method was not remarkable difference. (C) 2009 Elsevier Ltd. All rights reserved.
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